AgeDefying Bundle
Complete Anti-Aging System
Save 17% on this transformative collection
Experience the synergy of three revolutionary formulas that work in harmony to deliver comprehensive anti-aging results. This power trio combines advanced peptide science with breakthrough ingredients for unparalleled skin transformation.
Bundle Includes
- Daily Firming Serum (3% GHK-Cu)
- Line Lifting Serum (Botox Alternative)
- Daily Hydrating Cream (GHK-Cu + Goat's Milk)
Ingredients
AgeDefying Bundle Benefits
The Ultimate Anti-Aging Solution
Transform your skincare routine with this comprehensive system that targets every aspect of skin aging:
Morning: Apply Daily Firming Serum followed by Daily Hydrating Cream
Evening: Layer Line Lifting Serum under Daily Hydrating Cream
Special Care: Additional Line Lifting Serum application for expression-prone areas
Synergistic Anti-Aging Benefits
1. Collagen Enhancement
GHK-Cu technology stimulates:
- New collagen formation
- Skin structure improvement
- Enhanced elasticity
2. Wrinkle Reduction
Multi-pathway approach:
- Muscle relaxation (Line Lifting Serum)
- Collagen support (Daily Firming Serum)
- Deep hydration (Daily Hydrating Cream)
3. Cellular Protection
Comprehensive defense system:
- Advanced antioxidant protection
- UV damage prevention
- Enhanced skin barrier function
4. Progressive Results
Short-term benefits:
- Immediate hydration
- Visible smoothing
- Enhanced radiance
- Long-term transformation:
- Structural improvement
- Lasting firmness
- Reduced lines and wrinkles
The Power of Three
This carefully curated bundle represents the pinnacle of anti-aging science, combining our most powerful formulations for maximum results:
- Daily Firming Serum: The collagen catalyst
- Line Lifting Serum: The Botox alternative
- Daily Hydrating Cream: The moisture maximizer
Experience the transformative power of advanced peptide science and breakthrough ingredients working in perfect harmony to reveal your most youthful, radiant complexion.
Directions for Use
Experience the ultimate in anti-aging skincare with Entera Skincare's Ageless Bundle, featuring Luminose Daily Firming Serum, Daily Hydrating Cream and Line Lifting Serum. Follow these steps to incorporate these advanced products into your daily skincare routine for maximum efficacy and profound, lasting results.
For Daily Use (Face)
Cleanse and Tone:
- Begin with a clean face. Use your preferred cleanser and toner to remove impurities and prepare your skin for optimal absorption of the serums and cream.
Apply Line Lifting Serum:
- Dispense a small amount of the serum onto your fingertips.
- Gently massage the serum onto your face, focusing on areas prone to expression lines and dynamic wrinkles, such as around the eyes, mouth, and forehead.
- Use upward, circular motions to ensure even distribution and absorption.
- Allow the serum to fully absorb into the skin.
Apply Daily Firming Serum:
- Dispense a small amount of the serum onto your fingertips.
- Gently massage the serum onto your face, focusing on areas prone to fine lines and wrinkles.
- Use upward, circular motions to ensure even distribution and absorption.
- Allow the serum to fully absorb into the skin.
Apply Hydrating Cream:
- Dispense a small amount of the cream onto your fingertips.
- Gently massage the cream onto your face, focusing on areas that need deep hydration and radiance.
- Use upward, circular motions to ensure even distribution and absorption.
For Enhanced Results
Evening Routine:
- Use all three products as part of your nightly skincare routine to support deep hydration, skin regeneration, and repair while you sleep.
- Apply the Line Lifting Serum first, followed by the Daily Firming Serum, and finish with the Hydrating Cream.
Combine with Other Treatments:
- For targeted treatments, layer the serums under other skincare products and apply the cream afterward as recommended by your skincare professional.
Consistency is Key:
- Use the serums and cream consistently, morning and night, to achieve cumulative benefits and long-term improvements in skin hydration, texture, and elasticity.
For Targeted Body Use
Cleanse:
- Use your preferred body wash to cleanse the areas you intend to treat.
Apply Line Lifting Serum:
- Dispense a small amount of the serum onto your fingertips.
- Massage the serum into targeted areas of concern, such as the neck, décolletage, arms, or any other areas prone to sagging and wrinkles.
- Use circular motions to ensure even coverage and absorption.
Apply Daily Firming Serum:
- Dispense a small amount of the serum onto your fingertips.
- Massage the serum into the same targeted areas treated with theLine Lifting Serum for enhanced anti-aging effects.
- Use circular motions to ensure even coverage and absorption.
Apply Hydrating Cream:
- Dispense a small amount of the cream onto your fingertips.
- Massage the cream over the serum-applied areas for enhanced hydration and firming effects.
- Use circular motions to ensure even coverage and absorption.
Tips for Optimal Use
- Less is More: A small amount of each product goes a long way. Use sparingly to avoid product wastage.
- Patch Test: If you have sensitive skin, perform a patch test before applying the products to larger areas.
- Storage: Store the serums and cream in a cool, dry place, away from direct sunlight, to maintain their potency and efficacy.
Pro Tip
- Apply after showering when your skin is slightly damp to lock in extra moisture and enhance absorption.
Elevate your skincare routine with the luxurious, scientifically-proven benefits of the AgeDefy Bundle. Transform your skin with the power of GHK-Cu and advanced peptides for a youthful, radiant complexion that defies age. Embrace the future of beauty with Entera Skincare today.
The Proven Science Behind GHK-Cu
At Entera Skincare, we believe in transparency and evidence-based skincare. Our Luminose Daily Firming Serum's star ingredient, GHK-Cu, is backed by extensive scientific research. Here's what the studies say:
1. UV Protection and Antioxidant Effects
Research has shown that GHK-Cu protects keratinocytes from lethal Ultraviolet B (UVB) radiation, offering significant photoprotection for your skin.
- Blocks formation of reactive oxygen species
- Regulates copper levels and modifies expression of antioxidant genes
- Detoxifies products of lipid peroxidation
Source: Pickart, L., et al. (2015). GHK-Cu may Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes. Cosmetics, 2(3), 236-247.
2. Skin Regeneration and Healing
GHK-Cu demonstrates remarkable potential in promoting healing processes and skin regeneration.
- Enhances skin remodeling and tissue regeneration
- Exhibits strong anti-inflammatory properties
- Promotes collagen, elastin, and glycosaminoglycan synthesis
- Supports dermal fibroblast function
Source: Pickart, L., et al. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences.
3. Anti-Aging Effects
Studies have shown that GHK-Cu can significantly improve various signs of skin aging.
- Improves skin density, thickness, and clarity
- Reduces fine lines and wrinkles
- Increases integrin expression and p63 positivity in keratinocytes, promoting their proliferation
Source: Dou, Y., et al. The potential of GHK as an anti-aging peptide. Vol. 2, Iss: 1, pp 58-61.
4. Wound Healing and Tissue Repair
GHK-Cu plays a crucial role in wound healing and tissue repair processes.
- Stimulates collagen synthesis in fibroblasts
- Enhances the survival of basal stem cells in the skin
- Protects against cortisone-induced inhibition of wound healing
Source: Kang, Y.A., et al. (2009). Copper–GHK increases integrin expression and p63 positivity by keratinocytes. Archives of Dermatological Research.
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Summary of Research on Syn-Ake, EGF, Argireline, and Leuphasyl
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate)
- Mechanism: Syn-Ake mimics the effects of Waglerin-1, a peptide found in the venom of the Temple Viper. It inhibits neuromuscular activity, reducing muscle contractions.
- Benefits: Reduces the appearance of expression lines and wrinkles.
Studies:
- In vitro: Demonstrated muscle-relaxing properties by blocking acetylcholine receptors.
- Clinical: Showed a reduction in wrinkle depth by up to 52% after 28 days of treatment in some studies.
- Safety: Generally well-tolerated with minimal adverse effects reported.
EGF (Epidermal Growth Factor)
- Mechanism: EGF is a polypeptide that stimulates cell growth, proliferation, and differentiation by binding to its receptor (EGFR).
- Benefits: Promotes skin regeneration, reduces wrinkles, improves skin elasticity and hydration.
Studies:
- In vitro: Accelerates keratinocyte proliferation and enhances fibroblast activity.
- Clinical: Demonstrated improvements in skin texture, reduction in fine lines, and increased collagen production. Notable studies show significant skin regeneration and anti-aging effects over several weeks of use.
- Safety: Effective with good tolerability; however, long-term safety data is limited and requires further study.
Argireline (Acetyl Hexapeptide-8)
- Mechanism: Argireline inhibits the SNARE complex, leading to reduced neurotransmitter release and muscle contraction.
- Benefits: Reduces the depth of wrinkles, especially around the eyes and forehead.
Studies:
- In vitro: Reduces catecholamine release, thus decreasing muscle contractions.
- Clinical: Showed a significant reduction in wrinkle depth (up to 30% after 30 days of treatment). Often referred to as "Botox in a jar" due to its muscle-relaxing effects.
- Safety: Well-tolerated with minimal side effects; some studies suggest potential irritation in sensitive skin.
Leuphasyl (Pentapeptide-18)
- Mechanism: Leuphasylmimics the natural enkephalins in the body and interferes with the neuronal SNARE complex, reducing muscle contractions.
- Benefits: Decreases the appearance of dynamic wrinkles.
Studies:
- In vitro: Demonstrated effective reduction of muscle cell contraction.
- Clinical: Combined with other peptides like Argireline, it shows synergistic effects, further reducing wrinkle depth and skin smoothness. Studies show a reduction in wrinkle depth by 11-16% after 28 days
- Safety: Good safety profile with minimal adverse reactions reported.
General Observations
- Combined Use: Many studies suggest enhanced benefits when these peptides are used in combination, as they target different mechanisms of wrinkle formation.
- Efficacy: These peptides are effective primarily in reducing dynamic wrinkles caused by muscle contractions. Their efficacy in static wrinkles (caused by skin aging and loss of elasticity) is less pronounced.
- Safety: Generally safe and well-tolerated, though some peptides may cause irritation in sensitive individuals. Long-term safety data is limited, necessitating further research.
Conclusion
- Syn-Ake, EGF, Argireline, andLeuphasylhave shown promising results in reducing wrinkles and improving skin texture through various mechanisms. Their combined use may offer synergistic benefits, and they are generally safe with minimal side effects. Further studies, especially long-term and comparative trials, are needed to fully understand their efficacy and safety profiles.
References:
- Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake): Clinical Efficacy and Safety.Journal of Cosmetic Dermatology.
- EGF and Skin Rejuvenation: Clinical and In Vitro Evidence.Dermatologic Surgery.
- Argireline: Mechanism of Action and Clinical Efficacy.International Journal of Cosmetic Science.
- Peptide-Based Wrinkle Treatments: Comparative Analysis ofLeuphasyland Argireline.
- Clinical, Cosmetic and Investigational Dermatology.
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